Cov khoom
Polyinosinic acid-polycytidylic acid
Cov qauv qauv
Lub cev
Cov tsos mob: dawb los yog tawm-dawb hmoov
Qhov ntom.
Melting point.
Boiling point.
Refractivity
Flash point.
Cov ntaub ntawv kev nyab xeeb
Qeb phom sij.
Tus Naj Npawb Tsheb Thauj Khoom Loj.
Ntim qeb.
Daim ntawv thov
Poly I: C paub tias muaj kev cuam tshuam nrog tus xov tooj zoo li tus neeg txais xov tooj 3 (TLR3), uas tau nthuav tawm ntawm cov kab mob endosomal ntawm B-cells, macrophages thiab dendritic hlwb.
Yam ntxwv
Cov khoom no yog ib qho hluavtaws interferon inducer, uas yog ob-stranded polyribonucleotide muaj li ntawm polyinosinic acid thiab polycytidylic acid.Txij li thaum interferon yog hom tshwj xeeb, nws yog ib qho nyuaj rau kev npaj ntau ntau rau kev kho mob, yog li nws feem ntau yog siv los ua interferon inducer rau induce interferon.Tsis tas li ntawd, polyinosinic acid tseem muaj lub luag haujlwm ntawm lub cev tiv thaiv kab mob, uas tuaj yeem txhawb nqa cov kab mob reticuloendothelial, txhim kho phagocytic kev ua haujlwm ntawm phagocytes, txhim kho kev tsim cov tshuaj tiv thaiv kab mob, txhawb kev tiv thaiv allograft thiab ncua kev tsis haum tshuaj.Nws muaj broad-spectrum antiviral thiab antitumor teebmeem.
Siv cov txheej txheem synthesis
Txheej txheem cej luam
Polycytidylic acid, tseem hu ua polyinosinic acid, polyhypoxanthine nucleotide thiab polycytidine nucleotide, yog ib qho ntawm cov polynucleotides, uas muaj ob-stranded polynucleotide saw ntawm polyinosinic acid thiab polycytidylic acid, nrog cov yam ntxwv decolorization thiab melting point, thiab ruaj khov ntawm -20 ℃ .
Pharmacological teebmeem
1. Polyinosinic acid muaj kev txhawb nqa zoo rau ob qho tib si tshwj xeeb thiab tsis muaj kev tiv thaiv ntawm lub cev.
(1) Polymyocytes txhim khu kev ua haujlwm ntawm lub cev tiv thaiv kab mob
(2) Polymyocytes txhawb kev tso tawm ntawm ntau yam cytokines
(3) Induction ntawm Mx protein los ntawm polymyocytes
(4) Polymyocytes txhawb kev tsim cov tshuaj tiv thaiv hauv vivo
2. Anti-viral nyhuv ntawm polymyocytes
Hauv kev sim vitro, kev sim tsiaj thiab kev sim tshuaj tib neeg tau ua pov thawj tias polymyxins muaj ntau yam tshuaj tiv thaiv kab mob, suav nrog tus kab mob ua npaws daj, kab mob encephalomyelitis, Rift Valley fever virus, kab mob khaub thuas avian, kab mob siab, kab mob AIDS, kab mob ko taw thiab qhov ncauj. kab mob kab mob, kab mob conjunctivitis, kab mob pob khaus yooj yim, kab mob Mengo, kab mob pox, kab mob myocarditis, Aleutian virus, coxsackievirus, thiab lwm yam. Nws tau raug pov thawj tias kev tiv thaiv ntawm Polymyxa zoo dua li kev kho mob ntawm tus kab mob.
Daim ntawv thov
1.A ob-stranded homopolymer uas tuaj yeem siv los ua tus qauv RNA los kawm txog cell signaling ntawm qib TLR3 paub txog ob-stranded RNA, uas tseem yog lub ntsiab lus tseem ceeb ntawm kev tiv thaiv kab mob rau cov kab mob kis.
2.Paired nrog polyinosinic acid los tsim polyinosinic cell, siv rau kev kho mob ntawm tus kab mob siab kab mob siab, herpes zoster, herpes simplex keratitis, herpes stomatitis, epidemic hemorrhagic fever, thiab lwm yam.
3. Nws muaj kev tiv thaiv kab mob adjuvant, nkoos reticuloendothelial system, txhim khu phagocytosis, txhim kho cov tshuaj tiv thaiv kab mob, stimulates allograft cov tshuaj tiv thaiv thiab ncua kev tsis haum tshuaj.Adjuvant kho cov qog.Cov kev phiv tshwm sim feem ntau suav nrog kev mob ntshav qab zib tsis zoo thiab ib tus neeg mob kub taub hau siab tshaj 38 ℃, uas feem ntau txo qis ntawm nws tus kheej hauv 1-2 hnub.
