Cov khoom
Doxifluridine
Cov qauv qauv
Lub cev
Cov tsos: dawb Khoom
Ceev: 1.3751 (kwv yees)
Melting taw tes: 188-192 ° C (Lit.)
Kev sib hloov tshwj xeeb: d25 + 18.4 ° (c = 0.419 Hauv Dej)
Refractivity: 20 ° (C = 1, H2O)
Cia txias: inert atmosphere, chav kub
Acidity Factor (PMA): 7.4 (ntawm 25 ℃)
Cov ntaub ntawv kev nyab xeeb
Hazard qeb: Cov khoom tsis txaus ntshai
Cov Khoom Uas Phom Nyom Tsis Tau:
Packing qeb:
Daim ntawv thov
1. Raws li kev tawm tsam ntawm 5-flurouridine.Ib qho fluorinated pyrimidine nucleoside nrog cytostatic kev ua haujlwm.Clinically siv rau mob qog noj ntshav, mob qog nqaij hlav hauv plab, mob qog noj ntshav mis, tus nqi tso tawm tuaj yeem ncav cuag ntau dua 30%
2. Ua ib qho nruab nrab rau Fluorouracil antitumor tshuaj
Taw qhia txog kev siv
1. Fluorouracil-based antitumour agents yog cov ua ntej rau fluorouracil.Lub enzyme thymidine phosphorylase, uas muaj nyob rau hauv cov ntaub so ntswg, ua rau nws hloov mus rau hauv fluorouracil nyob rau hauv cov qog, yog li exerting ib tug anti-tumour nyhuv.Nws muaj qhov muaj zog tiv thaiv qog tshwj xeeb thiab tsis muaj tshuaj lom.Nws yog siv hauv kev kho mob qog noj ntshav, mob qog noj ntshav thiab mob qog noj ntshav, nrog rau kev tshem tawm txog li 30% lossis ntau dua.
2. Cov chaw kuaj tshuaj nruab nrab.
3. Nws yog ib tug antitumour agent, ib tug precursor tshuaj ntawm fluorouracil (5-FU), uas yog hloov mus rau hauv dawb fluorouracil los ntawm kev ua ntawm pyrimidine nucleoside phosphorylase nyob rau hauv cov qog nqaij hlav, yog li inhibiting lub biosynthesis ntawm DNA thiab RNA nyob rau hauv cov qog hlwb thiab qhia nws. antitumour nyhuv.Txij li thaum cov haujlwm ntawm cov enzyme no siab dua hauv cov ntaub so ntswg ntau dua li cov ntaub so ntswg ib txwm muaj, kev hloov pauv ntawm 5-FU mus rau 5-FU hauv cov ntaub so ntswg yog ceev thiab xaiv rau cov qog.Nws yog siv los kho cov qog nqaij hlav hauv lub mis, plab thiab qhov quav thiab muaj toxicity tsawg.
