Dexamethasone

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Khoom npe: Dexamethasone
CAS Nr .: 50-02-2
EINECS tus lej ID: 200-003-9
Cov mis mos molecular: C22H29FO5
Molecular Luj: 392.47

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Product Detail

Khoom cim npe

Cov qauv qauv

Lub cev
Qhov tsos: dawb hmoov
Qhov ceev: 1.1283
Melting point: 262-264 ° C
Kub taw tes: 568.2 ± 50.0 ° C

Cov ntaub ntawv kev nyab xeeb
Yam khoom muaj nqis: General khoom

Daim ntawv thov
Nws yog tsuas yog siv rau anti-inflammatory thiab anti allergic.Nws yog tsim rau rheumatoid mob caj dab thiab lwm yam kab mob collagen.

Dexamethasone (DXMS) tau tsim thawj zaug hauv xyoo 1957 thiab tau teev nyob rau hauv WHO Cov Tshuaj Tseem Ceeb Standard List ua ib qho tshuaj tseem ceeb rau cov kab ke kev noj qab haus huv pej xeem.
Thaum Lub Rau Hli 16, 2020, WHO tau hais tias qhov kev sim tshuaj ntsuam xyuas ua ntej hauv tebchaws United Kingdom tau pom tias dexamethasone tuaj yeem cawm neeg txoj sia nyob rau hauv cov neeg mob uas muaj mob ntsws neocoronary, txo cov neeg tuag li ntawm ib feem peb rau cov neeg mob ntawm lub tshuab ua pa thiab li ntawm ib feem tsib rau cov neeg mob. oxygen xwb.
Dexamethasone yog ib qho hluavtaws corticosteroid uas tuaj yeem siv los kho ntau yam mob, suav nrog cov kab mob rheumatic, qee yam ntawm cov tawv nqaij, kev ua xua hnyav, mob hawb pob, mob ntsws ntsws, mob ntsws, ncaj ncees laryngitis, cerebral edema, thiab tejzaum nws ua ke nrog tshuaj tua kab mob hauv cov neeg mob. tuberculosis.Nws muaj kev ntsuam xyuas cev xeeb tub ntawm C hauv Tebchaws Meskas, uas yuav tsum tau muaj kev ntsuam xyuas tias qhov ua tau zoo ntawm cov tshuaj muaj ntau dua cov kev mob tshwm sim ua ntej nws tuaj yeem siv tau, thiab qhov ntsuas ntawm A hauv tebchaws Australia, uas qhia tau tias feem ntau siv rau cov poj niam cev xeeb tub. thiab hais tias tsis muaj pov thawj ntawm fetal raug mob.

Pharmacological teebmeem
Dexamethasone, tseem hu ua flumethasone, fluprednisolone, thiab dexamethasone, yog glucocorticoid.Nws cov derivatives muaj xws li hydrocortisone, prednisone, thiab lwm yam. Nws cov tshuaj pharmacological tsuas yog los tiv thaiv kev mob, tiv thaiv tshuaj lom, tiv thaiv kev ua xua thiab tiv thaiv rheumatic, thiab nws yog dav siv hauv kev kho mob.Nws cov ntshav T1/2 yog 190 feeb thiab cov ntaub so ntswg T1/2 yog 3 hnub.Cov ntshav siab tshaj plaws ntawm dexamethasone sodium phosphate lossis dexamethasone acetate nce mus txog l teev thiab 8 teev tom qab txhaj tshuaj intramuscular.Cov plasma protein khi tus nqi ntawm cov khoom no yog qis dua li ntawm lwm cov corticosteroids.Cov tshuaj tiv thaiv kab mob ntawm 0.75 mg yog sib npaug rau 5 mg ntawm prednisolone.Adrenocorticosteroids, anti-inflammatory, anti-allergic thiab anti-toxic teebmeem muaj zog dua li ntawm prednisone, thiab cov teebmeem ntawm sodium retention thiab potassium excretion yog lub teeb heev.
1. Anti-inflammatory nyhuv: Nws tuaj yeem txo thiab tiv thaiv cov ntaub so ntswg teb rau o, yog li txo qhov tshwm sim ntawm o.Cov tshuaj hormones inhibit qhov sib xyaw ntawm cov hlwb, nrog rau cov macrophages thiab leukocytes, ntawm qhov chaw ntawm qhov mob thiab inhibit phagocytosis, tso tawm lysosomal enzymes, thiab synthesis thiab tso tawm cov tshuaj kho mob ntawm qhov mob.
2. Immunosuppressive teebmeem: nrog rau kev tiv thaiv lossis inhibiting cell-mediated immune teb, ncua kev tsis haum tshuaj, txo tus naj npawb ntawm T lymphocytes, monocytes, thiab eosinophils, txo cov peev txheej ntawm immunoglobulins rau cell nto receptors, thiab inhibiting synthesis thiab tso tawm ntawm interleukins. , yog li txo qhov hloov pauv ntawm T lymphocytes rau lymphoblasts thiab txo qis kev nthuav dav ntawm thawj lub cev tiv thaiv kab mob.Nws txo qhov kev nkag mus ntawm lub cev tiv thaiv kab mob los ntawm cov ntaub ntawv hauv qab daus thiab txo cov concentration ntawm cov khoom xyaw ntxiv thiab cov tshuaj immunoglobulins.
Nws tau yooj yim nqus los ntawm GI ib puag ncig, nrog ntshav plasma T1/2 ntawm 190 feeb thiab cov ntaub so ntswg T1/2 ntawm 3 hnub.Cov ntshav siab tshaj plaws tau mus txog 1 teev thiab 8 teev tom qab txhaj tshuaj intramuscular ntawm dexamethasone sodium phosphate lossis dexamethasone acetate, raws li.Cov plasma protein binding tus nqi ntawm cov khoom no yog qis dua lwm yam corticosteroids, thiab cov tshuaj tiv thaiv kab mob ntawm cov khoom no 0.75 mg yog sib npaug rau 5 mg ntawm prednisolone.

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Tom ntej: Tyrosol