Bucladesine

Lus piav qhia luv luv:

Lub npe: Bucladesine
Lub Npe: N-6,O-2′-Dibutyryl adenosine cyclic 3′:5′-monophosphate;N-(9-beta-D-Ribofuranosyl-9H-furin-6-yl)-butyramide cyclic 3′,5′-(hydrogen phosphate) 2′-butyrate
CAS Nr .: 16980-89-5
EINECS tus ID nkag mus: 241-059-4
Cov mis mos molecular: C18H23N5NaO8P
Molecular Luj: 491.37

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Product Detail

Khoom cim npe

Cov qauv qauv

Lub cev muaj zog
Tsos: Dawb khoom crude khoom
Cia txias: -20 ° C
Solubility H2O: 50 mg/mL

Cov ntaub ntawv kev nyab xeeb
Nws belongs rau cov khoom siv

Daim ntawv thov
Dibutyryl cyclic adenosine monophosphate sodium yog derivative ntawm cyclic adenosine monophosphate, uas yog siv los kho cardiogenic poob siab thiab lub plawv tsis ua hauj lwm.Xyoo 1999, Dibutyryl cyclic adenosine monophosphate sodium ointment tau tsim los kho cov kab mob ntawm daim tawv nqaij thiab kab mob ntawm daim tawv nqaij.

Kev npaj ntawm sodium dibutyryl cyclophosphate adenosine: Nyob rau hauv lub khob uas muaj cyclophosphate adenosine maj mam ntxiv aqueous sodium hydroxide tov (3 mol / L) dropwise, tus txheej txheem tswj kub, dropwise tiav ua kom sov rau chav tsev kub, kho pH rau 7 ~ 8 nrog HCl tov ( 20%), ntxiv anhydrous ethanol nag lossis daus ntawm cov khoom dawb, pom, ziab kom tau cov khoom dawb sodium ntsev;cov sodium ntsev thiab n-butyl anhydride nyob rau hauv kev tiv thaiv ntawm N2 sov so rau 140 ℃ cov tshuaj tiv thaiv.TLC saib xyuas, cov tshuaj tiv thaiv ua tiav thiab tom qab ntawd txo qis rau hauv chav tsev kub, maj mam ntxiv methyl tert-butyl ether, cov txheej txheem ntawm kev sib zog ua kom muaj zog, Cov Khoom Siv Tshuaj kom tau txais cov khoom lag luam yuav luag dawb.Kev sib xyaw ntawm methyl tert-butyl ether thiab acetone tau raug tshem tawm kom tau txais cov khoom siv hmoov dawb.Biological activityDibutyryl-cAMP(Bucladesine, dbcAMP) yog ib lub cell-permeable PKA activator uas ua los ntawm mimicking endogenous cAMP.Dibutyryl-cAMP(Bucladesine) kuj yog ib tug phosphodiesterase (PDE) inhibitor.
Kev tshawb fawb hauv vitro: Dibutyryl-cAMP inhibits neuronal qabzib uptake ntawm PKA ua kom.Hauv kab lis kev cai nas hepatocytes, Dibutyryl-cAMP inhibits inducible nitric oxide synthase qhia thiab NF-kappaB binding kev ua.dibutyrChemicalbookyl-cAMP kuj inhibits TNFalpha-induced rod cell apoptosis los ntawm inhibiting FADD upregulation.
Hauv kev tshawb fawb vivo: Hauv tus qauv nas, Bucladesine (600nM / nas, ip) thim rov qab zinc chloride thiab lead acetate induced evasive memory retention impairment.

Yav dhau los: Tuam Tshoj Diphenylacetonitrile Chaw tsim tshuaj paus

Tom ntej: 4,4′-Bis (dimethylamino) Thiobenzophenone