Cov khoom
5-Fluorocytosine
Cov qauv qauv
Lub cev
Qhov tsos: Dawb hmoov
Qhov ceev: 1.3990 (kwv yees)
Melting point: 298-300 ° C (lub kaum hli ntuj) (lit.)
Boiling point.
Refractivity
Flash point.
Cov ntaub ntawv kev nyab xeeb
Qeb phom sij.
Tus Naj Npawb Tsheb Thauj Khoom Loj.
Ntim qeb.
Daim ntawv thov
Flucytosine los ntawm lub qhov ncauj yog siv rau kev kho mob ntawm cov kab mob loj los ntawm cov kab mob Candida los yog Cryptococcus neoformans.Nws kuj tseem siv tau rau kev kho mob chromomycosis (chromoblastomycosis), yog tias muaj kab mob ua rau kis tau.Flucytosine yuav tsum tsis txhob siv los ua ib tus neeg sawv cev ntawm cov kab mob fungal uas ua rau muaj kev phom sij rau lub neej vim muaj cov tshuaj tiv thaiv kab mob tsis muaj zog thiab kev txhim kho sai ntawm kev tiv thaiv, tab sis yog ua ke nrog amphotericin B thiab / lossis azole antifungals xws li fluconazole lossis itraconazole.Cov kab mob me xws li candidal cystitis tuaj yeem kho nrog flucytosine ib leeg.Hauv qee lub tebchaws, kev kho mob nrog cov tshuaj tua kab mob qeeb tsis pub dhau ib lub lis piam kuj yog ib txoj kev kho mob, tshwj xeeb tshaj yog tias tus kab mob ua rau muaj kev phom sij rau lub neej.
Cov kab mob fungal loj tuaj yeem tshwm sim hauv cov neeg uas muaj kev tiv thaiv kab mob.Cov neeg no tau txais txiaj ntsig los ntawm kev kho ua ke nrog rau flucytosine, tab sis qhov tshwm sim ntawm cov kev mob tshwm sim ntawm kev sib xyaw ua ke, tshwj xeeb nrog amphotericin B, tej zaum yuav siab dua.
5-Fluorocytosine yog siv los kho cov kab mob fungal tshwm sim los ntawm Cryptococcus thiab Candida, xws li fungal sepsis, endocarditis, meningitis, thiab tshuaj tua kab mob rau lub ntsws thiab urinary ib ntsuj av.
Yam ntxwv
Cov khoom no muaj cov tshuaj tiv thaiv kab mob siab tiv thaiv Candida spp.thiab Candida spp.thiab tseem muaj cov tshuaj tua kab mob tiv thaiv kab mob Bacillus spp.thiab Mycobacterium spp.Cov khoom yog antibacterial ntawm tsawg concentration thiab fungicidal ntawm siab concentration.Lub mechanism ntawm kev txiav txim yog los thaiv cov synthesis ntawm fungal nucleic acid.Cov fungus yog ib qho yooj yim los tsim kev tiv thaiv rau cov khoom no.
Cov kev ceev faj
Ua ke nrog amphotericin B, nws muaj cov nyhuv synergistic, tab sis nws tuaj yeem txo qhov tso tawm ntawm cov khoom no los ntawm lub raum thiab ua kom cov ntshav siab, uas tuaj yeem ua rau muaj kev phom sij hauv lub raum thiab cov ntshav.Yog li ntawd, cov ntshav siab tshaj plaws yuav tsum tau saib xyuas thiab tswj ntawm 50-75μg / ml, tsis pub tshaj 100μg / ml;Kev siv cov pob txha pob txha inhibitors tuaj yeem ua rau kom cov hematologic toxicity ntawm cov khoom no.
Cov khoom no tuaj yeem ua rau ① xeev siab, raws plab, ua pob, thiab lwm yam;② daim siab puas tsuaj, feem ntau ua rau siab ua haujlwm siab, tab sis kuj hepatomegaly los yog hepatic necrosis;③ myelosuppression leukocyte thiab platelet txo, qee zaus tuaj yeem ua rau tag nrho cov ntshav cytopenia.Kev tuag ntawm granulocytic leukocyte deficiency thiab remitting anemia kuj tau qhia;④ kev hnov lus, mob taub hau thiab vertigo kuj tau tshaj tawm.Yog li ntawd, siv ceev faj rau cov neeg mob uas muaj kab mob siab lossis lub raum tsis zoo, cov ntshav tsis txaus, thiab cov pob txha pob txha.Daim duab ntawm cov ntshav peripheral, daim siab thiab lub raum ua haujlwm thiab cov zis niaj hnub yuav tsum tau kuaj xyuas tsis tu ncua thaum siv cov khoom no.Nws muaj cov nyhuv teratogenic hauv kev kuaj tsiaj, thiab yuav tsum tau siv nrog ceev faj hauv cov poj niam cev xeeb tub.
Cov tshuaj tiv thaiv tsis zoo muaj xws li nce transaminases, alkaline phosphatase, cov tsos mob ntawm plab hnyuv, leukopenia, anemia, thrombocytopenia, lub raum tsis zoo, mob taub hau, tsis pom kev, hnov lus, hnov lus tsis zoo, dyskinesia, txo cov ntshav poov tshuaj, calcium thiab phosphorus cov txiaj ntsig (kev tsis haum tshuaj), .
