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2-Amino-5-chlorobenzophenone

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Khoom npe: 2-Amino-5-chlorobenzophenone
CAS Nr .: 719-59-5
EINECS tus lej ID: 211-949-7
Cov mis mos molecular: C13H10ClNO
Molecular Luj: 231.68

Product Detail

Khoom cim npe

Cov qauv qauv

5
Lub cev

Cov tsos mob: daj crystalline hmoov
Qhov ceev: 1.33
Melting point: 96-98 ° C (lit.)
Kub taw tes: 207 ° C
Refractivity: 1.6000 (kwv yees)
Lub teeb taw tes: 211 ° C

Cov ntaub ntawv kev nyab xeeb
General

Daim ntawv thov
Ib qho metabolite ntawm Diazepam;nws muaj ib tug ntau zog anticonvulsant nyhuv.

Pharmaceutical intermediates.Kev tsim cov tshuaj xws li Librium thiab Valium.
Kev cuam tshuam ib puag ncig
Muaj kev phom sij me ntsis rau cov dej, tsis txhob cia cov khoom tsis muaj dej los yog cov khoom loj tuaj rau hauv av, dej los yog cov kav dej phwj tuaj, thiab tsis txhob tso cov khoom pov tseg rau hauv ib puag ncig yam tsis tau tso cai los ntawm tsoomfwv.

Khoom thiab Stability
Nyob ruaj khov ntawm ambient kub thiab siab, tsis txhob sib cuag nrog oxides

Txoj kev khaws cia
Khaws lub thawv kaw kom nruj thiab khaws cia rau hauv qhov chaw txias, qhuav hauv ib lub thawv ntim kom nruj.

Synthesis method
(1) Ua los ntawm cov tshuaj tiv thaiv ntawm p-chloroaniline nrog benzoyl chloride.Ntxiv p-chlorobenzene rau lub khob-lined cov tshuaj tiv thaiv lub lauj kaub ntawm 70 ° C lossis qis dua, muab tso rau hauv anhydrous zinc chloride, ntxiv benzoyl chloride dropwise nrog nplawm, ces tsa qhov kub thiab txias, tuav ntawm 195-205 ° C rau 2h, ntxuav tsib zaug nrog Cov dej kub ntawm 90-95 ° C (cov dej txheej thiab cov tshuaj ntxuav dej rov qab benzoic acid thiab zinc chloride) ntawm li 100 ° C, ntxiv sulfuric acid maj mam, tuav ntawm 142 ° C rau 40min.Cov khib nyiab yog precipitated hauv dej.Nyob rau hauv stirring, lub pH yog kho nrog kua alkali kom tsis txhob siab tshaj 1 thiab lim ntawm 20-25 ° C.Cov lim dej tau zoo li p-chloroaniline.Lub ncuav mog qab zib lim yog tov thiab muab tshem tawm hauv dej, nruab nrab rau pH = 6, lim kom qhuav, ntxuav nrog dej kom nruab nrab thiab qhuav kom tau cov khoom nyoos.Tom qab ntawd ntxiv 6-7 zaug ethanol, 6% activated carbon, reflux rau 30min, lim thiab crystallize, qhuav kom tau cov khoom zoo.(2) p-Nitrochlorobenzene thiab cyanobenzyl nplhaib ua ke kom tau isoxazole, ces qhib lub nplhaib, qhov txo kom tau.

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