Cov khoom
3,3'- diindolylmethane hmoov
Kev piav qhia
3,3'-diindolylmethane yog cov tshuaj nruab nrab;Nws tuaj yeem pom nyob rau hauv ntuj phytochemicals teej tug mus rau Cruciferae Nroj Tsuag, acid catalyzed tshuaj tiv thaiv cov khoom, indole-3-methanol;Nws muaj kev ua haujlwm ntawm tus neeg sawv cev tiv thaiv qog;Nyob rau hauv cov xwm txheej ntawm cov concentration siab, cov derivative tsis tau tsuas yog ncaj qha mus ceev lub apoptosis ntawm tib neeg mob qog noj ntshav, tab sis kuj sensitize txoj kev mus induce lub apoptosis ntawm tib neeg cov qog nqaij hlav cancer;Chemicalbookdim induces G1 cell nplhaib inhibition nyob rau hauv tib neeg lub mis mob qog noj ntshav MCF-7 hlwb los ntawm mechanism thiab inclusion qhia;Dim yog ib qho muaj zog inhibitor ntawm mitochondrial h +-atpase;Raws li ib tug tshiab cog kev loj hlob txhawb nqa, dim thiab nws cov derivatives tau siv nyob rau hauv eco-friendly system kev tshawb fawb.
Product Info
CAS nr: 1968-05-4
Purity: ≥98%
Cov roj formula: C17H14N2
Formula Wt.246.31 Nws
Lub npe tshuaj: 3,3'-Diindolylmethane
Synonym: 3,3'-Diindolylmethane(DIM); Di(1H-indol-3-yl); tsob nroj: Indole; 3,3'-DIINDOLYLMETHANE,>=98%(HPLC);3,3'-METHYLENEBIS- 1H-INDOLE; 3,3'-MethylenebISINDOLE; 3,3'-MethylenediINDOLE; 3,3'-DIINDOLYLMETHANE
Melting Point: 167 ° C
Kub taw tes: 230 ° C
Solubility: Chloroform (Sparingly), Methanol (me ntsis)
Cov tsos mob: Off-dawb hmoov
Shipping thiab Cia
Cia stability Pom zoo cia kub -20 ° C.
Kev npaj qhov chaw indole (1.17 g, 10 mmol), CTAB (50% mol) thiab oxalic acid (50% mol) nyob rau hauv 25 ml ib leeg-caj dab puag ncig-hauv qab khob, ntxiv 5 ml dej deionized, do kom huv si rau 5 feeb thiab tom qab ntawd ntxiv aqueous formaldehyde tov (0.38 g tov, 5 mmol formaldehyde) dropwise.React rau 3 h ntawm chav tsev kub thiab nres cov tshuaj tiv thaiv.Cov tshuaj tiv thaiv tau muab rho tawm nrog 15 ml ntawm ethyl acetate nyob rau hauv peb qhov chaw, thiab cov organic theem tau sau thiab qhuav nrog anhydrous Na2SO4 rau 5 teev.Cov kuab tshuaj raug tshem tawm nyob rau hauv qhov txo qis thiab recrystallized los ntawm kev sib xyaw ntawm methanol thiab dej (methanol/H2ChemicalbookO = 10/1) kom muab cov khoom dawb 3,3'-diindolylmethane hauv 85% tawm los.Bioactivity3,3'-Diindolylmethane (DIM) yog lub hauv paus digestion khoom ntawm indole-3-carbinol, uas yog ib tug muaj peev xwm anticancer tshuaj nyob rau hauv cruciferous zaub.3,3'-Diindolylmethane (DIM) yog ib tug ntshiab muaj zog antagonist ntawm androgen receptor (AR) .
Cov kev tshawb fawb hauv vitro tau pom tias DIM yog cov khoom siv hluav taws xob zoo thiab kev txo qis, ua haujlwm los ntawm kev txhawb nqa ATM-tsav DDR-zoo li cov lus teb nrog rau NF-κB ciaj sia taus signaling.DIM tuaj yeem tiv thaiv qog cell invasion, angiogenesis, proliferation thiab induce apoptosis los ntawm modulating signaling pathways. xws li AKT, NF-κB thiab FOXO3.Nws tuaj yeem cuam tshuam cov tshuaj estrogen-induced noob qhia thiab induce endoplasmic reticulum kev nyuaj siab.chemicalbookDIM tuaj yeem hloov cov tshuaj estrogen metabolism thiab antagonize estrogen thiab androgen receptor kev ua.Hauv vivo cov kev tshawb fawb tau pom tias DIM muaj txiaj ntsig zoo tiv thaiv kab mob hluav taws xob tom qab ntau qhov kev tswj hwm.Hauv kev sim vivo, DIM muab kev tiv thaiv hluav taws xob lossis txo qis.Hauv cov ntaub so ntswg ib txwm, DIM qhib lub tshuab ATM.dIM tuaj yeem muab tshuaj rau cov nas los ntawm qhov ncauj txhaws (250 mg / kg) nrog bioavailability siab thiab tsis muaj mob t.
